Modelling through Modality: (Re)shaping Brexit

Chemical genetics: reshaping biology through chemistry.

To understand biological processes, biologists typically study how perturbations of protein functions affect the phenotype. Protein activity in living cells can be influenced in many different ways: by manipulation of the genomic information, by injecting inhibitory antibodies, or, more recently, by the use of ribonucleic acid-medicated interference (RNAi). All these methods have proven to be e...

Brexit and health services.

Electromechanical reshaping of costal cartilage grafts: a new surgical treatment modality.

OBJECTIVES/HYPOTHESIS Needle electrode-based electromechanical reshaping (EMR) is a novel, ultra-low-cost nascent surgical technology to reshape cartilage with low morbidity. EMR uses direct current to induce mechanical relaxation in cartilage that is first deformed into a required geometry, which in turn leads to permanent shape change. The objective of this study was to determine the effect o...

Brexit and Translational Research

In a historic referendum on June 23, 2016, the UK voted to leave the European Union (EU) after more than four decades of membership. For the time being, the UK is still a member of the EU until the UK government triggers Article 50 of the Lisbon Treaty–which probably won't happen before the end of 2016. A minimum of 2 years of negotiations will follow before theUK ceases to be an EUmember. This...

Bubbles, Blind-Spots and Brexit

In this paper we develop a well-established financial model to investigate whether bubbles were present in opinion polls and betting markets prior to the UK’s vote on EU membership on 23 June 2016. The importance of our contribution is threefold. Firstly, our continuous-time model allows for irregularly spaced time series—a common feature of polling data. Secondly, we build on qualitative compa...